Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction
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منابع مشابه
Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction.
AIMS Hypertrophic cardiomyopathy (HCM) is the commonest cause of sudden cardiac death in the young, with an excess of exercise-related deaths. The HCM sarcomere mutations increase the energy cost of contraction and impaired resting cardiac energetics has been documented by measurement of phosphocreatine/ATP (PCr/ATP) using (31)Phosphorus MR Spectroscopy ((31)P MRS). We hypothesized that cardiac...
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Hypertrophic cardiomyopathy (HCM) is a disease state with characteristic pathologic changes most likely to result in abnormalities of diastolic function. Indeed, HCM may well be considered a “poster child” for diastolic dysfunction, because pronounced ventricular hypertrophy is associated with a reduced left ventricular (LV) cavity. The pressurevolume relationship would almost certainly be shif...
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many patients with essential hypertension. To assess the determinants of the abnormal ejection fraction response to exercise, we performed radionuclide angiography at rest and during exercise in 41 hypertensive patients without coronary artery disease. In 22 patients (group 1), the ejection fraction increased more than 5% during exercise; in the other 19 patients (group 2), the ejection fractio...
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It has long been noted that while patients with familial hypertrophic cardiomyopathy due to cardiac troponin T (cTnT) mutations often suffer sudden cardiac death, they do not develop significant ventricular hypertrophy, suggesting that a distinct cellular mechanism apart from alterations in myocardial contractility is responsible. A new study has revealed that a single missense mutation in cTnT...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2015
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehv120